I have been managing several hundred desktop computers for the past 6 years or so and I have seen an actual infection in the last 2 or 3 years on any of these systems we manage. However, interestingly I have seen three different infections in the last month along, all new viruses and different on each system. Did McAfee and Symantec fall asleep this last month?
This situation is a little shocking since it has occured at three different client sites, which are utalizing different AV products, and have varied (but internally standardized) methods of defense in depth. So, where is the breakdown? With this third infection which I will be going out to work on this morning, I will likely update this post with the findings as to why this stuff is getting through. Then again, the client this morning is someone who we do not actively manage like our other clients, so there may be other underlying problems at work there.